▪ 약물의 분류: 진통제

▪ 임신부 약물등급(US FDA): C

▪ 임신부 안전 및 기형발생정보:
Cortisol (hydrocortisone) is a naturally occurring glucocorticoid. Glucocorticoid medication use during pregnancy has been associated with an increased risk of cleft palate and impaired fetal growth. Cortisol may be used during nursing.

▪ 모유수유부 약물등급(Medication and Mother’s MilK): L3

▪ 모유수유 안전 및 유해성정보:
Cortisol is a normal component of human milk. Concentrations in milk follow a diurnal rhythm, with the highest concentrations occurring around 7:00 am. In lactating rats, the administration of hydrocortisone was associated with alterations in the lipid composition of milk, but no changes were detected in the weight gain or serum lipid concentrations of the nursing pups. A 2008 report did not find that the use of antenatal corticosteroids in some preterm births altered milk composition, but when antenatal corticosteroids were administered between 28 and 34 weeks` gestation and delivery occurred 3 to 9 days later, milk volume was significantly reduced. In 2 case reports, depot corticosteroids in high doses were associated with a reversible cessation of lactation.

A 2015 study introduced a novel hypothesis that maternal stress and corticosteroids during gestation and lactation might affect the intestinal microflora of infants in ways that promote the growth of pathological organisms. They noted that the associations they found did not demonstrate causation. This hypothesis will require further evaluation.

▪ 한국마더세이프전문상담센터 DB 정보 (모태독성학2016):

1) 기형발생정보
하이드로코르티손에 노출된 후 추적된 임신부는 총 58례이었으며 초기 노출 후 자연유산율은 6.8%(4/58)이었다. 임신 37주 이전의 조산률은 0%, 2,500 g 미만의 저체중증은 1.9%(1/52)이었다.
주요기형발생은 1.9%(1/52): VSD(1)가 있었다.

2) 모유 수유 시 독성 및 적합성 정보
수유부-수유아 8쌍 중 젖량 감소 1례있었다.

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